Sofosbuvir/velpatasvir: A promising combination

Mathematical Modeling of Brain Cancer to Identify Promising Combination Treatments

For aggressive brain cancers such as glioblastoma multiforme (gbm), much of the discussion on this web site and others are on clinical trials for new agents. This is largely because the existing arsenal of treatments is so weak. The clinical trials take drugs that seem promising and test them for safety and efficacy. The trials have prevented widespread use of agents that were dangerous, and ha...

A promising method of knowledge acquisition using a combination of Bayesian network and Rough set theory

The determinant of survival in the knowledge-based economy is knowledge development and management, which usually starts with knowledge acquisition followed by knowledge organization and utilization. Although several studies demonstrate that data mining techniques and the rough sets theory (RST) are useful to knowledge acquisition, few people really enjoy or benefit from them in daily work and ...

Camphor as a promising insecticude for control

Apelin: A promising therapeutic target? (Part 1)

Apelin is a recently discovered bioactive peptide, known to be an endogenous high-affinity ligandfor the previously orphan G protein-coupled receptor APJ. Apelin/APJ as a novel signaling pathwayhas been shown to play many crucial roles in cardiovascular function, blood pressure regulation, fluidhomeostasis, feeding behavior, obesity, type 2 diabetes mellitus, adipoinsular axis regulation, cellp...

Combination of acamprosate and baclofen as a promising therapeutic approach for Parkinson’s disease

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic nigrostriatal neurons but which involves the loss of additional neurotransmitter pathways. Mono- or polytherapeutic interventions in PD patients have declining efficacy long-term and no influence on disease progression. The systematic analysis of available genetic and functional data a...